The Acura MDX Prototype was unveiled at the 2013 North American International Auto Show, the production version was revealed at the New York Auto Show. Production began on May 2, 2013; vehicle assembly shifted from Ontario, Canada to Lincoln, Alabama. US sales began on June 20.

The Pilot seats eight, as the MDX seats seven, with two seating positions in the 3rd row. The MDX has been the most expensive crossover in Acura's lineup, except for the 2009-13 model years when Acura added a crossover to slot above the MDX, Acura MDX 2025 called the ZDX. In 2003, the Honda MDX continued sale in Japan and Australia. In Japan, 2025 Acura MDX it filled a difference once the Honda Horizon (also based on the Trooper) was discontinued in 1999. The MDX was the first crossover SUV to possess third-row seating, and shares a platform with the Honda Pilot. The MDX was introduced as a 2001 model, replacing the slow-selling U.S.-only body-on-frame SLX, on the basis of the Isuzu Trooper.

The MDX is currently powered by way of a 3.5-liter direct injected Earth Dreams V6 with Variable Cylinder Management. A front-wheel drive (FWD) model can be obtained for the very first time in the United States, however, not in Canada, where all-wheel drive is the only configuration offered. EPA-estimated fuel economy is improved with all-wheel drive (SH-AWD) models rated at 18/27/21 mpg (city/highway/combined) and FWD models rated at 20/28/23 mpg.

The MDX rides lower reducing its center of gravity. Advance package models include further noise reduction employing a thicker carpet base layer and front fender liners. The inside reduced button clutter with the addition of a 7-inch touchscreen with haptic feedback, one more 8-inch screen can also be standard. The seating H-point has been reduced and the steering gear ratio is 9% quicker for a far more sporty feel. To lessen interior noise an audio (PVB layered) windshield, acoustic front door glass and thicker rear glass are utilized in addition to triple sealed door openings.

The alphanumeric moniker represents "Multi-Dimensional luxury ".According to Honda, the MDX could be the best-selling three-row luxury crossover of all time, with cumulative U.S. sales anticipated to surpass 700,000 units before the conclusion of 2014. It has ranked as the second-best selling luxury crossover after the Lexus RX, which provides only two rows of seats. The Acura MDX, or Honda MDX as known in Japan and Australia (only the first generation was imported), is a mid-size three-row luxury crossover, made by the Japanese automaker Honda under its Acura luxury nameplate since 2000.

The headlights are Acura's Jewel Eye LED Headlights (first introduced on the RLX). Based on Acura the outside is more aerodynamic reducing drag by 16% with the newest model lapping Nürburgring 8 seconds faster than its predecessor. Each headlamp uses five separate LED sources with three used for low-beam lighting and two for high-beam lighting. LED bumper mounted fog lamps are given as a dealer installed option.

A 3.0-liter V6, 7-speed dual-clutch hybrid was included with the lineup, a corner wheels are powered by twin electric motors and lithium-ion battery, and the hybrid is just obtainable in all-wheel drive, while the standard variant of the 2017 Acura MDX began sales in Summer 2016, the hybrid will debut and begin sales in Spring 2017 (April 2017).

The MDX also offers a variety of advanced technology features, including a user-friendly infotainment system and numerous safety and driver assistance features. The guts console often houses a prominent infotainment display that gives access to various functions, such as navigation, audio controls, and vehicle settings. Acura supplies a spacious cabin with comfortable seating for approximately seven passengers. The MDX typically features a well-designed and high-quality interior. The materials used in the cabin are generally of good quality, giving the automobile reduced feel. Acura MDX 2025's infotainment system usually includes features like smartphone integration like CarPlay and Android Auto, Bluetooth connectivity, and multiple USB ports. The MDX generally provides ample cargo space because of its class. The third-row seats can be folded down to create additional storage area when needed.

The driver's seat often comes with power-adjustable settings, including lumbar support. The MDX typically offers spacious and comfortable seating for up to seven passengers, with ample legroom and headroom in most three rows. The seats are usually upholstered in high-quality materials, such as for example leather, and are created to supply a supportive and luxurious driving experience. However, some reviewers have noted that the third-row seats may become more suitable for children or smaller adults due to limited legroom.

LED bumper mounted fog lamps are offered as a dealer installed option. Each headlamp uses five separate LED sources with three useful for low-beam lighting and two for high-beam lighting. In accordance with Acura the exterior is more aerodynamic reducing drag by 16% with the brand new model lapping Nürburgring 8 seconds faster than its predecessor. The headlights are Acura's Jewel Eye LED Headlights (first introduced on the RLX).