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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are often focused on the practical aspects of the study design, such as the recruitment process and consent, adherence, and the use of routinely available equipment.

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A pragmatic study that involves different investigators and participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is necessary for pragmatic trials to be valid and reduces the chance of bias in the results. A high degree of heterogeneity, however, can cause problems with the trial design.

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The purpose of pragmatic trials is to replicate real-life situations and achieve the highest level of validity externally. Usually, they are commissioned by policymakers and practitioners in order to inform their decisions. They are also a good method of determining the causal relationship between the intervention and its effects. However, they should not, 프라그마틱 슬롯 사이트 be used to replace the need for explanation studies.

The pragmatism concept is controversial and there are concerns about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which prove the clinical or physiological hypothesis, and pragmatic trials, which guide policy and practice decisions. They also proposed an approach to pragmatic trials, dubbed PRECIS.2 This tool was designed to define the characteristics of a pragmatic study which includes the recruitment process, the design and delivery of the intervention, and monitoring.

The number of pragmatic trials is increasing. A recent Medline search using the terms naturalistic and pragmatic, which was limited to randomized controlled trials (RCTs) resulted in 34 articles, 프라그마틱 슬롯 (mouse click the next document) which are shown in red in Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatic thinking. It is important to note, however, that the majority were conducted in primary-care settings.