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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are typically characterized by a focus on practical aspects of the study design, including the recruitment process and consent, adherence, and the use of routinely available equipment.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which employed different investigators and participants from different geographic areas. This kind of heterogeneity is essential for pragmatic trials to be able to prove their validity and also reduces bias in the results. Too much heterogeneity, however can result in problems with the design of the trial.

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Pragmatic trials seek to replicate real-world situations and have the highest external validity. Usually, 프라그마틱 공식홈페이지 무료게임 - visit the next document, they are ordered by policymakers and practitioners in order to inform their decisions. They are also a good method of determining the causality between an intervention and its results. However, they shouldn't be used to substitute for explanatory studies.

The pragmatism concept is controversial, and there are questions about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which validate the clinical or physiological hypothesis and pragmatic trials, which inform policy and practice decisions. They also proposed the framework for pragmatic trials, which they called PRECIS.2 This tool was designed to define the characteristics of a pragmatic study that include the recruitment process, the design and delivery of the intervention, as well as follow-up.

There is a growing trend in the number of pragmatic trials published. A recent Medline search using the terms naturalistic and pragmatic, which was limited to randomized controlled trials (RCTs), yielded 34 articles, 프라그마틱 정품 확인법 슬롯 (www.dermandar.com) shown in red in Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatism. It is important to note that the majority of these studies were conducted in primary care settings.