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Studies designed to provide insight into clinical practice in the real world are referred to as pragmatic trials. They are usually characterized by a focus on the practical aspects of the research design, like recruitment and consent as well as adherence to the use of routinely available equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which utilized various investigators and had participants from various geographical areas. This kind of heterogeneity is necessary for pragmatic trials to be able to prove their validity and also helps reduce bias in the results. A high degree of heterogeneity, however could cause issues with the design of the trial.

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The aim of pragmatic trials is to simulate real-life situations and achieve maximum validity externally. They are usually requested by policy makers and practitioners to guide their decision-making. They can be used to determine the causality of an intervention and its results. However, they shouldn't be used to substitute for explanation trials.

The pragmatism idea is controversial and there are concerns about whether pragmatic trials can replace tests for explanations or if they are an addition to them. Schwartz and Lellouch1 proposed the distinction between explanation studies, which confirm the validity of a physiological or clinical hypothesis, as well as pragmatic trials, 프라그마틱 슬롯 팁 which inform the practice and policy decision-making. They also proposed a framework called PRECIS for pragmatic trials.2 The tool was designed to define the characteristics of a practical study which includes recruitment, design, delivery of the intervention, and follow-up.

There is a positive trend in the number of pragmatic trials published. A recent Medline search using the terms naturalistic and pragmatic, which was limited to controlled trials that are randomized (RCTs) resulted in 34 articles, as shown in red in Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatism. However, it is important to keep in mind that the majority of these studies were conducted in primary care settings.