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Pragmatic trials are studies designed to provide information for the practice of clinical trials in real life. They are usually characterized by a focus on the practical aspects of research design, like the recruitment and consent process as well as adherence to the use of routinely available equipment.

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A practical trial that employs different investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity which is essential for a pragmatic trial to be reliable and reduce bias in results, is also necessary. However excessive heterogeneity could result in problems with the design of the trial.

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The aim of pragmatic trials is to simulate real-life scenarios and to achieve the highest level of validity externally. They are typically commissioned by policymakers and practitioners to inform their decisions. They can also be used to determine the causal relationship between an intervention with its outcomes. They should not, however be used to replace the need for explanation studies.

The idea of pragmatism is controversial and there are concerns regarding whether pragmatic trials could replace tests for explanations or if they are an alternative to them. Schwartz and Lellouch1 made a distinction between explanatory studies, which support the validity of a physiological or 프라그마틱 슬롯 사이트 clinical hypothesis, as well as pragmatic trials, which inform the practice and policy decision-making. They also suggested a framework dubbed PRECIS for pragmatic trials.2 The tool was designed to define the traits of a pragmatic research study, including recruitment, design, delivery of the intervention and follow-up.

There is a growing trend in the number of pragmatic trials published. A recent Medline search using the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs), returned 34 articles. They are displayed in red on Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatic thinking. However, it is important to keep in mind that the majority of these studies were conducted in primary care settings.